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pentobarbital will lessen the level or result of mestranol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.Barbiturates can induce hepatic microsomal enzymes leading to greater metabolism and reduced anticoagulant reaction of oral anticoagulants (eg, warfarin, acenocoumarol, dicumarol, and phenprocoumon); individuals s